Just to re-iterate
@Chris T's point...
Simplify the problem. On a car with an inline 4 cylinder engine... there is one exhaust manifold, one downpipe, one cat, one exhaust system.
Cats are made up of materials that will, overtime, breakdown and disintegrate. Just like everything else in life, they are not made to last forever, they will deteriorate at some point. In this system though... the debris will just flow out the back, and you'll only ever find out that something is wrong when you fail an emissions test. At this point, in a simple system, you just replace the front cat.
Now move on to a slightly more complicated system... a V6 engine with 2 manifolds, 2 downpipes, 2 cats (one for each downpipe) and then merging into 1 exhaust system (the same way the E50 is set up). Again... same as above... over time they will break down and flow out the back and no harm done... if you fail emissions, it's because the cat has failed and needs replacing.
The problem with the quad cat set up is that the front cats (that do 99% of the work) will have the same life expectancy of the cats in the above 2 examples. The problem being that the rear cats (which ONLY work for cold start emissions, so you won't find a quad cat set up on an EU/UK car) provide a barrier, the debris gets caught, and the blockage occurs. The other issue with the quad cat set up is that the first cats are located CLOSER to the manifold, meaning they get hotter than cats in single/dual cat systems as they are placed further back.
The problem, I believe, is exacerbated in the UK by using inferior quality fuel. From what I can tell... although the engine will run perfectly well on 95 ron unleaded fuel... you will cause premature detonation of the front cats as the engine will run hotter, and therefore exhaust gasses are hotter, which means MORE wear on the cats. If you use 99 ron (Tesco Momentum for example), you will slow the rate at which the front cats deteriorate, but it won't STOP it.
If you convert to LPG your exhaust gasses are considerably hotter, and therefore will break the front cats down even quicker than using 95 ron unleaded. But as LPG burns cleaner, you can just remove ALL the cats and test on LPG rather than Petrol and it will still meet emissions testing requirements.
The BEST and ONLY solution to this problem is to remove the rear cats so that any debris does not create a blockage.